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What are platinum complexes?

What are platinum complexes?

Platinum complexes like cisplatin and carboplatin (Fig. 13.7) exert their antitumor effects by forming DNA adducts and subsequent inhibition of DNA replication and transcription. They have an important role in the treatment of several solid tumors.

What are cis platinum complexes used for?

Cisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, breast cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. It is given by injection into a vein.

Which platinum complex is used in cancer treatment?

The metal based compounds nowadays are used to treat cancer. Platinum complexes are used in treating cancer patients by its application in cancer chemotherapy treatment. Cisplatin is the first platinum complex which was observed to have anticancer activity.

What are side effects of platinum complex?

Other common side effects include anaphylaxis, cytopenias (including leukopenia and neutropenia, thrombocytopenia, and anaemia), hepatotoxicity, ototoxicity, cardiotoxicity, nausea and vomiting, diarrhea, mucositis, stomatitis, pain, alopecia, anorexia, cachexia, and asthenia.

Why is platinum in chemotherapy?

The platinum compounds are largely used in the treatment of lung, breast, ovarian, and colon cancers. The chemotherapeutic mechanism of platinum compounds is typical of DNA-binding alkylating agents. If the DNA damage exceeds the ability of the cell to repair, the cell undergoes apoptotic cell death.

Which metal is used for cancer therapy?

Platinum drugs, such as cisplatin, carboplatin and oxaliplatin, are the mainstay of the metal-based compounds in the treatment of cancer, but the delay in the therapeutic accomplishment of other metal-based compounds hampered the progress of research in this field.

What is platinum chemo?

Platinum-based antineoplastic drugs (informally called platins) are chemotherapeutic agents used to treat cancer. They are coordination complexes of platinum. These drugs are used to treat almost half of people receiving chemotherapy for cancer.

What is platinum used for?

Platinum is used in catalytic converters, laboratory equipment, electrical contacts and electrodes, platinum resistance thermometers, dentistry equipment, and jewelry.

What are the side effects of platinum complexes?

What are the harmful effects of platinum?

Other Long-Term Effects * Platinum may cause a skin allergy. If allergy develops, very low future exposure can cause itching and a skin rash. * Platinum may cause an asthma-like allergy. Future exposure can cause asthma attacks with shortness of breath, wheezing, cough, and/or chest tightness.