What is Sledai score?

SLEDAI-2 K is a global index that generates a total score reflecting an overall disease activity but is capable of measuring disease activity in each of the nine organ systems if required.

How do you score Sledai 2K?

SLEDAI-2K. SLEDAI-2K is based on the presence of 24 descriptors in nine organ systems over the preceding 30 days. Descriptors of SLEDAI-2K are documented as present or absent. Each of the descriptors has a weighted score and the total score of SLEDAI-2K is the sum of all 24 descriptor scores.

What is the Bicla?

Background/Purpose: BICLA is a validated composite global measure of SLE disease activity that incorporates BILAG, an instrument that distinguishes between partial and complete improvement. BICLA was an endpoint in the phase 3 TULIP-1 and TULIP-2 trials of anifrolumab.

What should the sledai-2 K score be?

Each of the descriptors has a weighted score, and the total score of SLEDAI-2 K is the sum of all 24 descriptor scores. The total SLEDAI-2 K score falls between 0 and 105. A score of 6 is considered clinically important and affects the decision to treat with a probability of initiating therapy in more than 50 % of cases.

When did The SLEDAI clinical index come out?

The SLEDAI is a global index that was developed and introduced in 1985 as a clinical index for the assessment of lupus disease activity in the preceding 10 days. It consists of 24 weighted clinical and laboratory variables of nine organ systems.

What is the total score for SELENA SLEDAI?

patient’s SELENA-SLEDAI total score is the sum of all marked SLE-related descriptors. A total score can fall between 0 and 105, with a higher score representing a more significant degree of disease activity.1,2 Trademarks are owned by or licensed to the GSK group of companies.

What is the Slam score for systemic lupus?

Systemic Lupus Activity Measure-Revised (SLAM-R) includes 23 clinical manifestations in nine organs/systems and seven laboratory features and has a possible range of 0 to 81; a score of at least 7 is considered clinically important because it is associated with a probability of initiating therapy in more than 50 %…