Is band 41 Lyme specific?

What is the significance of band 41 on the IgM and IgG Western blot? It is not Lyme specific and the CDC requires more bands to be present before a diagnosis. However, it is a band for bacteria so what else could cause that to be positive if not Lyme? The 41 kd band is often found on the Western blot.

What is Lyme WB IgG band 41?

The 41 band indicates an antibody to the flagella 41 kDa protein and is nonspecific. The 31 kDa band represents the OSPA protein and is specific for just a few species of Borrelia, as is the 34 band OSPB, and 23 kDa OSPC. etes or gum disease spirochetes.

What does a positive IgG band 41 mean?

Results indicated that testing for an increased CD4/CD8 ratio with a positive IgG band 41 was effective for diagnosing Lyme disease, compared with current guidelines. The mean CD4/CD8 ratio was 2.41 among the 148 patients tested.

How do you know when Lyme disease is gone?

As with many infectious diseases, there is no test that can “prove” cure. Tests for Lyme disease detect antibodies produced by the human immune system to fight off the bacteria (Borrelia burgdorferi) that cause Lyme disease. These antibodies can persist long after the infection is gone.

How long does Lyme IgG stay positive?

IgG antibodies are slower to develop, beginning to show 4-6 weeks after exposure and may peak 4-6 months after exposure. While IgM tends to be associated with an active infection, both IgM and IgG can persist in the blood for many years.

When is IgM positive for Lyme disease 3.1?

A positive single-tier IgG 2 WB test for Lyme disease 3. 1 IgM WB is considered positive when at least two of the following three bands are present: 24 kilodalton (kDa) outer surface protein C (OspC)*, 39 kDa basic membrane protein A (BmpA), and 41 kDa (Fla). Disregard IgM results for specimens collected >30 days after symptom onset.

Is there a band 23 for Lyme disease?

Band 23 is specific to Lyme disease ( www.anapsid.org/cnd/diffdx/wb.html) – meaning that no other disease will trigger a response to this band.

What are the symptoms of band 23 IgM?

Samjones, Band 23 IgM is reactive. As far as symptoms, I’ve had headaches, dizziness , and tinnitus for 14 months now. I’ve tried multiple neuologists,ENT’s, etc. and now just trying to find something, which is why we did the test. I also had a case of epididymis a couple of months ago.

Can a positive Lyme blot be a false positive?

If the positive test is an IgG Western blot or a C6 Lyme ELISA, it is very unlikely that either test would be falsely positive. Fourth, a positive test may indicate that you did have some of the signs or symptoms of Lyme disease in the past but didn’t recognize the problem as Lyme disease.