How is FFP calculated?

The recommended adult therapeutic dose of FFP is 12-15 ml/kg (1), and the dose of FFP should always be at least 10 ml/kg (2); however a recent report showed in clinical practice 40% of adults received a FFP dose <10 ml/kg (2).

How much FFP do you give in DIC?

A guideline for initial FFP dosing is 10-15 mL/kg; this typically translates to at least 4 units of FFP to effect a therapeutic response.

How long does FFP last in the body?

Note how the FFP produced only a partial correction of the elevated PT (B) while the vitamin K completely reversed the coagulopathy (D). The therapeutic effect of FFP lasted for approximately 7-8 hours (C).

Why do we give FFP for high INR?

In the latter settings the interlaboratory agreement may be poor and the bleeding risks poorly correlated with INR. The purpose of FFP transfusion is to lower the risk of bleeding in patients with coagulopathy. However, studies have found no difference in bleeding events in patients receiving FFP compared to those not.

How long should FFP be transfused?

A unit of FFP is usually administered over 30 minutes. 170 – 200 micron filter is required (standard blood administration set). Once thawed, cryoprecipitate must not be re-frozen and should be used immediately. If delay is unavoidable, the component should be stored at ambient temperature and used within 4 hours.

Can FFP reverse heparin?

Vitamin K, and in emergency conditions, PCC, or FFP can be used for warfarin reversal, whereas protamine sul- fate reverses the effects of heparin completely. Fondaparinux and LMWH do not have effective reversal agents; however, protamine (for LMWH) and rFVIIa or activated PCC (for fon- daparinux) may have some value.

Is there formula for FFP for warfarin reversal?

Thus, with these 2 INR goals, one can tabulate the units of FFP needed for various INR levels. Tables 1 and 2 summarize the clinical utility of Rashidi and Tahhan’s formula for the vast majority of clinical scenarios and provide a facile algorithm to appropriately dose FFP for warfarin reversal.

How to calculate the units of FFP after 1 FFP?

Using the formula provided by the authors of DeltaINR after 1 FFP= 0.57 x PreINR − 0.72, where DeltaINR = PreINR − PostINR, it is not a simple task to derive a facile formula for calculating the units of FFP needed. The only solution provided by the authors is an iterative approach until the goal INR is reached.

When to use fresh frozen plasma ( FFP )?

FFP is used to treat conditions in which there are low blood clotting factors (INR>1.5) or low levels of other blood proteins. The fresh frozen plasma is used as a part of plasma exchange. Use this online calculator to determine the Fresh Frozen Plasma (FFP) in a patient’s blood using the weight as the parameter.

How big of a PCC is needed for FFP?

FFP: Fresh Frozen Plasma Warfarin Life or Brain Threatening Bleeding: 4-factor PCC (Kcentra) If INR 2-4: 25 units/kg (not to exceed 2500 units) If INR 4-6: 35 units/kg (not to exceed 3500 units) If INR > 6: 50 units/kg (not to exceed 5000 units)