What is the substrate for acetyl CoA carboxylase?

What is the substrate for acetyl CoA carboxylase?

Acetyl-CoA carboxylase (ACC) catalyses the formation of malonyl-CoA, an essential substrate for fatty acid synthesis in lipogenic tissues and a key regulatory molecule in muscle, brain and other tissues.

How is acetyl CoA carboxylase produced?

ACCase is a biotin-dependent carboxylase that produces malonyl-CoA from bicarbonate as a source of carboxyl group, and adenosine triphosphate (ATP) as a source of energy. ACCase catalyzes the conversion of acetyl-CoA into malonyl-CoA through the incorporation of a carboxyl group into the acetyl radical of acetyl-CoA.

What is the product of the acetyl CoA carboxylase reaction?

Acetyl-CoA carboxylase (ACC) is a biotin-dependent enzyme that catalyzes the irreversible carboxylation of acetyl-CoA to produce malonyl-CoA through its two catalytic activities, biotin carboxylase (BC) and carboxyltransferase (CT).

What happens when acetyl CoA is abundant?

As such, the expression of these growth genes is closely coupled to acetyl-CoA as an indicator of the cell’s nutritional state. Thus, when carbon sources are abundant, nucleocytosolic amounts of acetyl-CoA accumulate and facilitate the processes of lipid synthesis and histone acetylation (Fig. 1).

Where is acetyl-CoA produced?

Acetyl-CoA is synthesized in mitochondria by a number of reactions: oxidative decarboxylation of pyruvate; catabolism of some amino acids (e.g., phenylalanine, tyrosine, leucine, lysine, and tryptophan); and β-oxidation of fatty acids (see earlier).

Where is acetyl CoA produced?

What is acetyl CoA and why is it important?

acetyl CoA: Acetyl coenzyme A or acetyl-CoA is an important molecule in metabolism, used in many biochemical reactions. Its main function is to convey the carbon atoms within the acetyl group to the citric acid cycle (Krebs cycle) to be oxidized for energy production.