What is methylated histone H3K9?

What is methylated histone H3K9?

H3K9 methylation is a histone modification that is a well-known indicator of silenced transcription and heterochromatin structure. Fission yeast has a single H3K9 methyltransferase (Clr4/KMT1) that is responsible for all three states of H3K9 methylation93 and regulates silencing at pericentromere and mating-type loci.

What does histone methylation do?

Methylation of histones can either increase or decrease transcription of genes, depending on which amino acids in the histones are methylated, and how many methyl groups are attached. This process is critical for the regulation of gene expression that allows different cells to express different genes.

What do deacetylases do?

Publisher Summary. Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups from an amino acid on a histone. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation.

Which is an inhibitory modulator of H3K4 methylation?

At the chromatin level, the H3K4 methylation effector Wdr5 and several chromatin-remodeling proteins, such as Bgr1 and Baf155, have been shown to promote iPSC generation 9, 10. Recently, Dot1l, which regulates histone H3 lysine 79 (H3K79) methylation, was identified as an inhibitory modulator of reprogramming 11.

Which is the epigenetic determinant of H3K9 methylation?

Here, we show that histone H3 lysine 9 (H3K9) methylation is the primary epigenetic determinant for the intermediate pre-iPSC state, and its removal leads to fully reprogrammed iPSCs.

How are H3K9 methyltransferases function as downstream targets of BMPs?

Mechanistically, we identified H3K9 methyltransferases as downstream targets of BMPs and showed that they function with their corresponding demethylases as the on/off switch for the pre-iPSC fate by regulating H3K9 methylation status at the core pluripotency loci.