Is undifferentiated pleomorphic sarcoma curable?

Summary. MFH is a curable disease. The term “Malignant Fibrous Histiocytoma” has been changed by the WHO to Undifferentiated Pleomorphic Sarcoma Not Otherwise Specified. The mainstays of treatment for MFH are complete surgical excision most often supplemented with adjuvant radiation therapy.

What is a pleomorphic sarcoma?

Overview. Undifferentiated pleomorphic sarcoma (UPS) is a rare type of cancer that begins mostly in the soft tissues of the body. Soft tissues connect, support and surround other body structures. UPS usually occurs in the arms or legs. Less often it can happen in the area behind the abdominal organs (retroperitoneum).

Is undifferentiated pleomorphic sarcoma aggressive?

Undifferentiated Pleomorphic Sarcoma, formerly called Malignant Fibrous Histiocytoma, is a rare subtype identified by a lack specific immunohistochemical markers for a specific lineage of differentiation. These soft tissue tumors are aggressive and rapidly enlarge.

How is undifferentiated pleomorphic sarcoma treated?

Treatment for undifferentiated pleomorphic sarcoma usually involves surgery to remove the cancer cells. Other options include radiation therapy and drug treatments (systemic therapies), such as chemotherapy, targeted therapy and immunotherapy.

What is the survival rate for undifferentiated pleomorphic sarcoma?

A 5-year overall survival rate of 48% has been reported for patients with head and neck tumors versus 77% for patients with tumors arising on the trunk and extremities. The childhood variant appears have better prognosis.

What are pleomorphic bacteria give an example?

Although it has recently been shown that certain bacteria are capable of dramatically changing shape, pleomorphy remains a controversial concept. A well accepted example of pleomorphism is Helicobacter pylori, which exists as both a helix-shaped form (classified as a curved rod) and a coccoid form.

What does it mean to have undifferentiated pleomorphic sarcoma?

Undifferentiated pleomorphic sarcoma (UPS), formerly referred to as malignant fibrous histiocytoma, is a type of soft tissue cancer. The word “undifferentiated” in undifferentiated pleomorphic sarcoma means that the cells don’t resemble the body tissues in which they develop.

What kind of soft tissue cancer is undifferentiated?

Undifferentiated pleomorphic sarcoma (UPS), formerly referred to as malignant fibrous histiocytoma, is a type of soft tissue cancer.

Where does pleomorphic histiocytoma ( ups ) usually occur?

Undifferentiated pleomorphic sarcoma (UPS), previously called malignant fibrous histiocytoma (MFH), is a soft tissue sarcoma (STS) that can occur anywhere in the body, but it usually occurs in the extremities (especially the thighs) or back of the abdomen (see the image below).

Are there any known risk factors for pleomorphic sarcoma?

Again, most people who develop undifferentiated pleomorphic sarcoma have no known risk factors, and many people who have risk factors never develop the cancer.