How are the clinical manifestations of folate and vitamin B12 deficiency similar How are they different?

In folate deficiency, homocysteine levels are elevated and MMA levels are normal. In vitamin B12 deficiency, both homocysteine levels and MMA levels are elevated.

What are the clinical manifestations of folate deficiency?

Common symptoms of folate deficiency can include: Tiredness, fatigue and lethargy. Muscle weakness. Neurological signs, such as a feeling of pins and needles, tingling, or burning, or peripheral neuropathy, i.e. a numbness in the extremities.

Is B12 or folate deficiency more common?

The best source of folate is green vegetables, such as broccoli, Brussel sprouts, asparagus and peas, and also chickpeas and brown rice. A vitamin B12 deficiency is rare in younger people, and is most common in people who are over 75 years of age. Folate deficiency is also most common in people over 75 years of age.

What are the most characteristic clinical manifestation of B12 vitamin deficiencies?

Characteristics/Clinical Presentation The most common sign of vitamin B12 deficiency is Fatigue. This is caused by the lack of red blood cells to carry oxygen to body tissue. Lack of red blood cells may also cause: Weakness.

Is folate and vitamin B12 the same thing?

Vitamin B12, also called cobalamin, is found in foods from animals, such as red meat, fish, poultry, milk, yogurt, and eggs. Folate (Vitamin B9) refers to a natural occurring form of the vitamin, whereas folic acid refers to the supplement added to foods and drinks.

What does low folate do to your body?

Vitamin B12 or B9 (commonly called folate) deficiency anaemia occurs when a lack of vitamin B12 or folate causes the body to produce abnormally large red blood cells that cannot function properly. Red blood cells carry oxygen around the body using a substance called haemoglobin.

What diseases cause low folate?

Folate deficiency can cause anemia. Anemia is a condition in which you have too few RBCs. Anemia can deprive your tissues of oxygen it needs because RBCs carry the oxygen. This may affect their function….Disease

• Crohn’s disease.
• celiac disease.
• certain types of cancers.
• severe kidney problems that require dialysis.

Does B12 deficiency cause malabsorption?

enterocyte caused by severe vitamin B12-deficiency, which is rapidly corrected by giving vitamin B12. Binding of intrinsic factor by intrinsic factor anti- bodies secreted into the gastric juice or bacterial overgrowth of the small bowel may contribute to the malabsorption in some patients.

Can you take folic acid and vitamin B12 together?

No interactions were found between folic acid and Vitamin B12. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

What foods are high in folate and B12?

You’ll most likely want to get your folate, vitamin B-12 and iron from other foods, as well. The best sources of folate include beans, lentils, asparagus, green leafy vegetables, avocado, broccoli, oranges, bread, mango, papaya and pomegranate.

What does a high level of B12 and folate mean?

High B12 and high folic acid are signs of hemochromatosis. Hemochromatosis can cause iron to build up in the body’s organs. My father died due to the build up of iron in his heart. I am now showing signs of damage to my liver.

What does high B12 blood levels really mean?

High blood B12 levels can occur in liver conditions such as cirrhosis and hepatitis. Alcoholic liver disease is an example of a liver condition associated with high vitamin B12 . With alcoholic liver disease, vitamin B12 as well as its carrier proteins can be elevated.

How can a B12 deficiency affect the metabolism?

Consuming efficient levels of vitamin B12 can increase your metabolism helping you lose the extra pounds. A deficiency in Vitamin B12 places stress on the body making it harder to be active and even perform day-to-day tasks. This can reduce your ability to lose weight.